FibroGuard

FibroGuard is a unique and complex mixture of bioflavanoids, polyphenols, spices, and plant and berry extracts contained in the proprietary formula ATNF-10. These compounds are some of the most researched and tested polyphenols and flavonoids available today. Individually these ingredients are renowned for their antioxidant, anti-inflammatory, neuroprotective, and cardiovascular protective effects.

In FibroGuard they have been combined to work in a cooperative fashion to reduce the pro-inflammatory effects of the immune system in chronic inflammatory states.

Certain bioflavanoids, plant extracts, and spices have been found to have significant antioxidant and anti-inflammatory effects in the human body.

Antioxidant Effects:

Antioxidant effects of flavenoids and polyphenol plant substances include binding up toxic free radicals, preventing cellular damage, and protecting proteins from radical and reactive oxygen species attack. They do this by gently attaching to and forming a protective soft mantle of antioxidants around the proteins. They can achieve a much higher local concentration than regular water soluble antioxidants like Vitamin C, and even more than certain fat soluble antioxidants like vitamin E and Lipoic Acid. It is thought that the ring-like planes of the molecule together with the flexible linkages joining them allow the polyphenol molecule to conform with high specificity to protein structures.

Anti-Inflammatory Effects:

The immune system contains some of the most potent and destructive agents in the body in order to eliminate harmful agents such as bacteria, viruses, and cancer cells. It is a complex, highly regulated system, and an imbalance in the mechanisms which control it have been implicated in a variety of diseases, both chronic and acute.

Chronic activation of the inflammatory component of the immune system can result in damage to critical organs such as the heart, kidney, brain, and hormone producing glands such as the thyroid, pancreas and adrenals. This generalized, low grade inflammation can sometimes go unnoticed, however the effects can be cumulative over time, often resulting in end organ damage.

As the level of over-activation of the immune system increases, healthy cells and organs of the body are sometimes specifically targeted. This auto-immune attack is theorized to be a possible cause of many chronic inflammatory based diseases, such as Chronic Fatigue, Firbromyalgia, Crohns disease, Ulcerative Colitis, cystic fibrosis, multiple sclerosis, and even chronic pulmonary and heart diseases.

The regulatory mechanisms which control this potent defence system are controlled by a number of key molecules, such as the master cytokines TNF-alpha and interleukin beta, or the universal stress sensor of the body cell, Nuclear Factor Kappa B (NFKB). Research has shown that a number of natural compounds can stabilize these key molecules and prevent the over-activation of the immune system, reducing overall pro-inflammatory signals and their cascading effects.

Pharmaceutical agents have been developed which completely shut down TNF alpha, and have been successfully used in a number of chronic inflammatory diseases. However their dollar cost is high and their complete blockage of TNF alpha can result in super-infections and immune system compromise because of their crippling of certain arms of the immune system. FibroGuard modulates the immune system naturally by naturally down-regulating, not blocking, inflammatory components of the immune system, allowing it to maintain its healthy protective role without becoming overactive and self destructive.

FibroGuard has been formulated using the highest quality ingredients on the market today; 99% pure crystalline Resveratrol from Switzerland, the purest form of Resveratrol available. Bio-Curcumin from India, the most researched and effective form of curcumin yet developed. PowerGrape extract from France, the polyphenol rich Bordeaux grape extract shown to reduce protein oxidation and inflammation. These specific ingredients are often only used in studies to prove their effectiveness, however when it comes to commercial products, ingredients of lesser quality are almost always substituted due to bottom line considerations such as price points and profit margins. When formulating FibroGuard, our commitment to providing an effective product which would replicate study results demanded that we use only the best ingredients available.

FibroGuard provides a multitude of health protective effects, from enhancing antioxidant protection, to specifically reducing the inflammatory activity of the immune system in chronic disease states. For those seeking consistent long term antioxidant protection, or for those who may benefit from gentle modulation of chronic inflammatory states, FibroGuard is an ideal health supplement.

RESVERATROL

Godichaud S, Krisa S, Couronné B, Dubuisson L, Mérillon JM, Desmoulire A,Rosenbaum J. Deactivation
of cultured human liver myofibroblasts by trans-resveratrol, a grapevine-derived polyphenol.
Hepatology. 2000 Apr;31(4):922-31.

Kozuki Y, Miura Y, Yagasaki K. Resveratrol suppresses hepatoma cell invasion independently of its
anti-proliferative action. Cancer Lett. 2001 Jun 26;167(2):151-6.

Chavez E, Reyes-Gordillo K, Segovia J, Shibayama M, Tsutsumi V, Vergara P, Moreno MG, Muriel P.
Resveratrol prevents fibrosis, NF-kappaB activation and TGF-beta increases induced by chronic
CCl4 treatment in rats. J Appl Toxicol. 2008 Jan;28(1):35-43.

CURCUMIN

Oakley F, Meso M, Iredale JP, Green K, Marek CJ, Zhou X, May MJ, Millward-Sadler H, Wright MC,
Mann DA. Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and
accelerated recovery from rat liver fibrosis. Gastroenterology. 2005 Jan;128(1):108-20.

Elsharkawy AM, Oakley F, Mann DA. The role and regulation of hepatic stellate cell apoptosis in
reversal of liver fibrosis. Apoptosis. 2005 Oct;10(5):927-39. Review.

Osawa T. Nephroprotective and hepatoprotective effects of curcuminoids. Adv Exp Med Biol. 2007;
595:407-23. Review.

Farombi EO, Shrotriya S, Na HK, Kim SH, Surh YJ. Curcumin attenuates dimethylnitrosamine-induced
liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food Chem Toxicol. 2008
Apr;46(4):1279-87. Epub 2007 Sep 26.

Priya S, Sudhakaran PR. Curcumin-induced recovery from hepatic injury involves induction of
apoptosis of activated hepatic stellate cells. Indian J Biochem Biophys. 2008 Oct;45(5):317-25.

GRAPE EXTRACT

Bagchi D, Sen CK, Ray SD, Das DK, Bagchi M, Preuss HG, Vinson JA. Molecular mechanisms of
cardioprotection by a novel grape seed proanthocyanidin extract. Mutat Res. 2003
Feb-Mar;523-524:87-97. Review.

Vitseva O, Varghese S, Chakrabarti S, Folts JD, Freedman JE. Grape seed and skin extracts inhibit
platelet function and release of reactive oxygen intermediates. J Cardiovasc Pharmacol. 2005
Oct;46(4):445-51.

BLUEBERRY EXTRACT

Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects. Br J Nutr. 2002 Oct;88(4):389-98.

Takeshita M, Ishida Y, Akamatsu E, Ohmori Y, Sudoh M, Uto H, Tsubouchi H, Kataoka H.
Proanthocyanidin from blueberry leaves suppresses expression of subgenomic hepatitis C virus
RNA. J Biol Chem. 2009 Aug 7;284(32):21165-76. Epub 2009 Jun 16. PubMed PMID: 19531480;

GREEN TEA EXTRACT

Sakata R, Ueno T, Nakamura T, Sakamoto M, Torimura T, Sata M. Green tea polyphenol epigallocatechin-3-gallate inhibits platelet-derived growth factor-induced proliferation of human hepatic stellate cell line LI90. J Hepatol. 2004 Jan;40(1):52-9.

Chen JH, Tipoe GL, Liong EC, So HS, Leung KM, Tom WM, Fung PC, Nanji AA. Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants. Am J Clin Nutr. 2004 Sep;80(3):742-51.

VITAMIN E